Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
Supplement Facts
Serving Size:  1 Tablet
Amount Per Serving
%DV
Iron (as ferrous sulfate)
65 mg
361%

Top Medical Research Studies

8
CUR-PDT triggers ferroptosis in RA
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.

Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.

This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.

We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).

These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.

Most Useful Reviews

8
Enhanced well-being
The quality is superb. I ordered it for my pregnant friend, and she is thrilled with the results. The taste is pleasant and easy to swallow, and she noticed improved overall well-being and energy after a few months. I recommend it to all expectant mothers.
4
Caused constipation
4 people found this helpful
I've used this nearly every day to increase my ferritin levels, but it caused constipation. However, the pills are easy to swallow, and I think it’s good despite this issue. I plan to try another brand next time, insha'Allah.
8
Improved iron levels
Great product! I ordered this for my mother, as she has a severe iron deficiency, and it has helped her significantly.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
  • All Researches
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.

We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).

These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
8
CUR-PDT triggers ferroptosis in RA
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.

Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.

This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.

User Reviews

USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8
Enhanced well-being
The quality is superb. I ordered it for my pregnant friend, and she is thrilled with the results. The taste is pleasant and easy to swallow, and she noticed improved overall well-being and energy after a few months. I recommend it to all expectant mothers.
4
Caused constipation
4 people found this helpful
I've used this nearly every day to increase my ferritin levels, but it caused constipation. However, the pills are easy to swallow, and I think it’s good despite this issue. I plan to try another brand next time, insha'Allah.
8
Improved iron levels
Great product! I ordered this for my mother, as she has a severe iron deficiency, and it has helped her significantly.

Frequently Asked Questions

8
Enhanced well-being
The quality is superb. I ordered it for my pregnant friend, and she is thrilled with the results. The taste is pleasant and easy to swallow, and she noticed improved overall well-being and energy after a few months. I recommend it to all expectant mothers.
4
Caused constipation
4 people found this helpful
I've used this nearly every day to increase my ferritin levels, but it caused constipation. However, the pills are easy to swallow, and I think it’s good despite this issue. I plan to try another brand next time, insha'Allah.
8
Improved iron levels
Great product! I ordered this for my mother, as she has a severe iron deficiency, and it has helped her significantly.
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.

We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).

These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
8
CUR-PDT triggers ferroptosis in RA
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.

Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.

This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.

References

  1. Shao W, Liu F, Zhu L, Qian W, Meng Q, et al. Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway. Eur J Pharmacol. 2025;987:177205. doi:10.1016/j.ejphar.2024.177205
  2. Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. doi:10.1007/s00011-025-02019-2
  3. Shin HG, Kim W, Lee JH, Lee HS, Nam Y, et al. Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI. Neuroimage Clin. 2025;45:103748. doi:10.1016/j.nicl.2025.103748
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